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Product details
Cat#：139P76
Three Letter Code: Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone trifluoroacetate salt
One Letter Code: Z-FK-ck
Synonyms: Z-FK-ck
Molecular Formula: C₃₄H₄₁N₃O₆
Relative Molecular Mass: 587.72
CAS#: 118253-05-7
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Details: Z-FK-ck is a very effective in vivo cathepsin B inhibitor in rats. It inhibited rat liver cathepsin B activity ex vivo with ED₅₀ = 5 mg/kg intraperitoneally and 18 mg/kg orally at 4-5 h postdose, and 2.4 mg/kg subcutaneously at 24 h postdose. It also inhibited rat cathepsin B activity in heart and skeletal muscle with ED₅₀ = 0.1 and 1.0 mg/kg subcutaneously at 20 h postdose. Z-FK-ck is an inhibitor of gingipain K.
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