Service hotline：+86-(0)-18115476705
Amide Cyclization
Amide Cyclization is other important way to form peptide cyclization and helix. Depending on its functional groups, a peptide can be cyclized in four different ways: head-to-tail (C-terminus to N-terminus), head-to-side chain, side-chain-to-side-chain, or side chain-to-tail. With our extensive experience in synthesizing cyclic peptides, TGpeptide can offer high quality amide cyclization peptides.
In order to form head-to-tail aminde cyclization, we use 2cl-resin. Protect the a-amino group using TFA, DDE group etc. and make the cleavage using low concentration TFA, we can manufacture high quality head-to-tail aminde cyclization peptide with high success rate.
Side-chain-to-side-chain aminde cyclization requires that there are more than two Lysine or Ornithine in the sequence. TGpeptide can make the side-chain-to-side-chain aminde cyclization before cleavage and after cleavage.
Besides of head-to-tail and side-chain-to-side-chain aminde cyclization, TGpeptide can manufacture head-to-side chain and side chain-to-tail aminde cyclization as well with high quality including RGD series peptides, you're welcome to contact if you have any questions or needs on them.
Copyright © Nanjing TGpeptide Biotechnology Co.,Ltd.
