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Product details
Cat#:139P78
Three Letter Code: Z-Phe-Tyr-aldehyde
One Letter Code: Z-FY-CHO
Synonyms: Z-FY-CHO, Cathepsin-L Inhibitor
Molecular Formula: C₂₆H₂₆N₂O₅
Relative Molecular Mass: 446.5
CAS#: 167498-29-5
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Osteoporosis Research
Details: Z-Phe-Tyrosinal is a potent and selective cathepsin L inhibitor. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.
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