Cat#：157P04
Three Letter Code: H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH trifluoroacetate salt(Disulfide bonds between Cys⁴ and Cys¹²/Cys⁷ and Cys¹⁵)
One Letter Code: NDDCELCVNVACTGCL
Synonyms: UGN (human), UGN Topoisomer A (human)
Molecular Formula: C₆₄H₁₀₂N₁₈O₂₆S₄
Relative Molecular Mass: 1667.88
CAS#: 154525-25-4
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Gastrointestinal Research| Obesity Research
Details: Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides. This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea. Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo.Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al. (2013)).