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Product details
Cat#：157P05
Three Letter Code: H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH trifluoroacetate salt(Disulfide bonds between Cys⁴ and Cys¹²/Cys⁷ and Cys¹⁵)
One Letter Code: NDDCELCVNVACTGCL
Synonyms: UGN Topoisomer B (human)
Molecular Formula: C₆₄H₁₀₂N₁₈O₂₆S₄
Relative Molecular Mass: 1667.88
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Gastrointestinal Research|
Obesity Research
Details: Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.
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