Cat#：159P05
Three Letter Code: H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt(Disulfide bonds between Cys⁷ and Cys²³/Cys¹⁰ and Cys¹³/Cys¹¹ and Cys¹⁹/Cys¹⁴ and Cys²²)
One Letter Code: DTHFPICIFCCGCCHRSKCGMCCKT
Synonyms: LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human)
Molecular Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉
Relative Molecular Mass: 2789.4
CAS#: 1356390-47-0
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Antimicrobial & Antiviral Peptides| Hematology
Details: Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0.