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Product details
Cat#：166P03
Three Letter Code: H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH
One Letter Code: AYC(Acm)RDGKIGPPKLDIRKEEKQI
Synonyms: (Tyr¹²¹,Cys(Acm)¹²²)-IFN-γ Receptor (120-141) (human)
Molecular Formula: C₁₁₅H₁₉₄N₃₄O₃₄S
Relative Molecular Mass: 2629.08
CAS#: 158040-83-6
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Details: This peptide derived from the ligand binding site of the human γ-interferon (IFN-γ) receptor is an antagonist of human IFN-γ. It inhibited human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC₅₀ of 35 µM. Immobilized peptide specifically bound recombinant human IFN-γ. Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide.
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