Cat#：176P06
Three Letter Code: H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH trifluoroacetate salt
One Letter Code: EKPKVEAYKAAAAPA
Synonyms: MBP (85-99) Peptide Antagonist
Molecular Formula: C₇₀H₁₁₄N₁₈O₂₁
Relative Molecular Mass: 1543.78
CAS#: 444305-16-2
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Antigen-presenting Cells| Multiple Sclerosis
Details: The antagonistic 15-peptide EKPKVEAYKAAAAPA competes with MBP (85-99), the immunodominant epitope of myelin basic protein (MBP), a major candidate autoantigen in multiple sclerosis (MS), for binding to human leukocyte antigen (HLA)-DR2. The peptide also inhibits IL-2 secretion by MBP (85-99) specific T-cell clones and induces the production of Th2 cytokines by splenocytes. Furthermore, it could be shown that the peptide is able to suppress experimental autoimmune encephalomyelitis (EAE) in several models in a manner that is equipotent to random amino acid copolymers, such as Copaxone [poly (Y,E,A,K)n]. Therefore, this synthetic peptide might be suitable in the studying of MS.