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Product details
Cat#：187P10
Three Letter Code: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH₂ trifluoroacetate salt
One Letter Code: RSGPPGLQGRLQRLLQASGNHAAGILTM-NH₂
Synonyms: Hypocretin-2 (human)
Molecular Formula: C₁₂₃H₂₁₂N₄₄O₃₅S
Relative Molecular Mass: 2899.38
CAS#: 205640-91-1
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Obesity Research
Details: Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX₁ receptor is significantly lower (IC₅₀ = 240 nM) than that of orexin A. Binding affinities for the OX₂ receptor are similar for orexin A and B (IC₅₀ = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor).
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