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/Renin Inhibitors and Substrates (16)
/DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS trifluoroacetate salt
Product details
Cat#：201P08
Three Letter Code: DABCYL-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS trifluoroacetate salt
One Letter Code: DABCYL-Abu-HPFHLVIHT-EDANS
Molecular Formula: C₉₀H₁₂₀N₂₂O₁₆S
Relative Molecular Mass: 1798.15
CAS#: 142988-22-5
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Cardiovascular System & Diseases
Details: The fluorogenic peptide substrate DABCYL-Abu-HPFHLVIHT-EDANS has been developed to continuously measure the proteolytic activity of human renin (Km = 1.5 µM at physiological pH). Cleavage of the FRET substrate occurs specifically at the Leu-Val bond and corresponds to the renin cleavage site of angiotensinogen. By means of this assay as low as 30 ng/mL renin can be detected after an incubation of only 3-5 min.
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