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/Secretase Inhibitors and Substrates (24)
/H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH
Product details
Cat#：203P18
Three Letter Code: H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH
One Letter Code: ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]AEF
Molecular Formula: C₄₂H₆₅N₇O₁₅
Relative Molecular Mass: 908.02
CAS#: 1349991-28-1
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Alzheimer´s Disease
Details: Glu-Leu-Asp-Leu-psi[CHOH-CH₂]-Ala-Ala-Glu-Phe (ELDL-psi[CHOH-CH₂]-AAEF), a potent inhibitor for human brain memapsin-2 (β-secretase) with a Ki-value of 0.3 nM. The hydroxyethylene isostere of the Leu-Ala motif functions as a mimic of the transition state.
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