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Product details
Cat#：203P21
Three Letter Code: Z-Ile-Leu-aldehyde
One Letter Code: Z-IL-aldehyde
Molecular Formula: C₂₀H₃₀N₂O₄
Relative Molecular Mass: 362.47
CAS#: 161710-10-7
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Alzheimer´s Disease
Details: Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid β (Aβ)-production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM). Besides blocking the formation of Aβ the dipeptide aldehyde Z-IL-CHO also blocks the production of the γ-CTF (γ-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-β-precursor protein (APP).
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