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/Somatostatin and Analogs (35)
/H-Tyr-Cys-Phe-Ala-Trp-Lys-Thr-Phe-Cys-OH trifluoroacetate salt (Disulfide bond)
Product details
Cat#：205P34
Three Letter Code: H-Tyr-Cys-Phe-Ala-Trp-Lys-Thr-Phe-Cys-OH trifluoroacetate salt (Disulfide bond)
One Letter Code: YCFAWKTFC
Molecular Formula: C₅₇H₇₁N₁₁O₁₂S₂
Relative Molecular Mass: 1166.39
CAS#: 647016-22-6
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Details: Selective somatostatin receptor subtype sst4 agonist. In competitive radioligand displacement experiments using the non-selective radioligand ([¹²⁵I]-(Leu⁸,D-Trp²²,Tyr²⁵)-Somatostatin-28, YCFAWKTFC exhibited a high affinity for sst4 with an IC₅₀ value of 2.0 ± 0.5 nM. IC₅₀ values for sst1, sst2, sst3, and sst5 were >1000 nM, 622 ± 85 nM, 624 ± 213 nM, and 692 ± 166 nM, respectively. The nonapeptide YCFAWKTFC may serve as a lead compound or tool for preclinical and clinical studies.
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