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Product details
Cat#: 107P139
Three Letter Code: H-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH
One Letter Code: EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV
Synonyms: NAC, α-Synuclein (61-95) (human), Non-β-Amyloid Component of Alzheimer´s Disease (NAC), Non-Aβ Component of Alzheimer´s Disease Amyloid
Molecular Formula: C₁₄₁H₂₃₅N₃₉O₄₉
Relative Molecular Mass: 3260.65
CAS#: 154040-19-4
Source: Synthetic
Storage Conditions: -20 ± 5 °C, avoid light, cool and dry place
Areas of Interest: Alzheimer´s Disease
Parkinson’s Disease
Details: The 35 amino acid peptide NAC (α-synuclein (61-95)) has originally been isolated from the insoluble core of Alzheimer´s disease (AD) amyloid plaque. The sequence corresponds to a fragment of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
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