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Product details
Cat#: 109P01
Three Letter Code: Ac-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH₂ (Disulfide bond)
One Letter Code: Ac-ALCDDPRVDRWYCQFVEG-NH₂
Synonyms: E-76
Molecular Formula: C₉₇H₁₃₉N₂₇O₂₉S₂
Relative Molecular Mass: 2211.47
CAS#: 1926163-13-4
Source: Synthetic
Storage Conditions: -20 ± 5 °C, avoid light, cool and dry place
Areas of Interest: Cardiovascular System & Diseases
Hematology
Details: The potent anticoagulant E-76, Acetyl-ALCDDPRVDRWYCQFVEG-amide, is an inhibitor of coagulation factor VIIa. It has been suggested that E-76 works by binding to an exosite on the factor VIIa protease domain, and non-competitively inhibits activation of factor X and amidolytic activity. E-76 has a well defined structure in solution determined by NMR spectroscopy that is similar to the X-ray crystal structure when complexed with factor VIIa and represents a new framework for the development of inhibitors for serine proteases.
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