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Product details
Cat#: 112P68
Three Letter Code: Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg)(Disulfide bonds between Cys³ and Cys¹⁶/Cys⁵ and Cys¹⁴/Cys⁷ and Cys¹²)
One Letter Code: Cyclo(-GICRCICGRGICRCICGR)
Synonyms: RC-100
Molecular Formula: C₇₄H₁₂₈N₃₀O₁₈S₆
Relative Molecular Mass: 1918.42
CAS#: 724760-19-4
Source: Synthetic
Storage Conditions: -20 ± 5 °C, avoid light, cool and dry place
Areas of Interest: Antimicrobial & Antiviral Peptides|
Infectious Disease
Details: The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors.
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