Cat#: 114P06
Three Letter Code: H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
One Letter Code: KFRRQRPRLSHKGPMPF
Synonyms: Preproapelin (61-77) (human, bovine, mouse, rat), Apelin Precursor (61-77) (human, bovine, mouse, rat)
Molecular Formula: C₉₆H₁₅₆N₃₄O₂₀S
Relative Molecular Mass: 2138.58
CAS#: 217082-57-0
Source: Synthetic
Storage Conditions: -20 ± 5 °C, avoid light, cool and dry place
Areas of Interest: Virology
Details: Apelin-17 is an endogenous ligand of the human orphan G protein-coupled receptor APJ, reported to act as a coreceptor of CD4 for human and simian immunodeficiency viruses. Apelin-17 and apelin-13 represent the predominant molecular forms of apelin present in the whole brain, hypothalamus, and plasma. Like apelin-13, apelin-17 exhibited a high activity on extracellular acidification rate and strongly inhibited forskolin-stimulated cAMP production in CHO cells expressing the human or the rat apelin receptor. The peptide might play a crucial role in the maintenance of body fluid homeostasis by counteracting AVP (arginine vasopressin) actions through inhibition of AVP neuron activity and AVP release.