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Product details
Cat#：126P18
Three Letter Code: H-Trp-Arg-Trp-Trp-Trp-Trp-NH₂ trifluoroacetate salt
One Letter Code: WRWWWW-NH₂
Molecular Formula: C₆₁H₆₅N₁₅O₆
Relative Molecular Mass: 1104.27
CAS#: 878557-55-2
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Alzheimer´s Disease
Details: Antagonist of formyl peptide receptor-like 1 (FPRL1) signalling. WRW4 inhibits WKYMVm binding to FPRL1 (IC₅₀ 0.23 mM) as well as the intracellular calcium release induced by WKYMVm, MMK-1, amyloid β42, and F peptide. The tryptophan-rich peptide also inhibits FPRL1-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by Aβ42. WRW4 inhibited the activation of FPRL2 by F2L, an FPRL2-selective endogenous agonist, resulting in the complete inhibition of intracellular calcium increase and chemotactic migration.
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