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Product details
Cat#：181P29
Three Letter Code: H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH₂ trifluoroacetate salt
One Letter Code: GPSQPTYPGDNATPEQMARYYSALRRYINMA-Aib-YQYR-NH₂
Synonyms: (Gly¹,Gln⁴·¹⁶,Thr⁶·¹³,Tyr⁷,Asp¹⁰,Asn¹¹,Pro¹⁴,Arg²⁶,Met³⁰,Ala³¹,Aib³²)-Neuropeptide Y (human, rat)
Molecular Formula: C₁₈₃H₂₈₁N₅₇O₅₄S₂
Relative Molecular Mass: 4207.73
CAS#: 313988-89-5
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Obesity Research
Details: This (Ala-Aib)-containing pancreatic peptide/neuropeptide Y chimera is a highly selective neuropeptide Y₅ receptor agonist. At this receptor this compound turned out to be 25-fold more potent than the derivative H-5084 (0.24 nM vs 6 nM) and three-fold more potent than the native ligand neuropeptide Y (H-6375) (0.24 nM vs 0.6 nM). This analog turned out to increase feeding approximately 2.5-fold more effective than neuropeptide Y.
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