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Product details
Cat#：183P12
Three Letter Code: H-Lys-psi(CH₂NH)Lys-Pro-Tyr-Ile-Leu-OH
One Letter Code: K-psi(CH₂NH)KPYIL
Synonyms: JMV 449, (Lys8-acetyl-Lys9)-Neurotensin (8-13)
Molecular Formula: C₃₈H₆₆N₈O₇
Relative Molecular Mass: 746.99
CAS#: 139026-66-7
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Cancer Research
Details: Replacement of the Lys⁸-Lys⁹ peptide bond by the CH₂NH bond produced an analog with quite interesting pharmacological properties. The degradation-resistant peptide analog Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu (JMV-449) was the most active in the binding and biological assays. JMV-449 exhibited higher binding and biological potencies than neurotensin. JMV449 was also about 10 times more potent than neurotensin (8-13) in the bioassay, whereas both peptides were equipotent in the binding assay.
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