In order to form hear-to-tail aminde cyclization, we use 2cl-resin. Protect the a-amino group using TFA, DDE group etc. and make the cleavage using low concentration TFA, we can manufacture high quality hear-to-tail aminde cyclization peptide with high success rate.

     Side-chain-to-side-chain aminde cyclization requires that there are more than two Lysine or Ornithine in the sequence. TGpeptide can make the side-chain-to-side-chain aminde cyclization before cleavage and after cleavage.

      Disulfide bonds are an integral component of the three-dimensional structure of many proteins. TGpeptide can offers the formation of cyclic peptides via disulfide bridges between cysteine residues within the peptide. We can synthesize peptides containing one to three disulfide bonds.

      Peptide stapling is a strategy for constraining short peptides in an alpha-helical conformation. The stapled peptides can be used for intracellular drug targets because stapling can increase the target affinity and proteolytic resistance.